Division of Science and Engineering - Faculty

Dr.  Thomas M. McGuire
Senior Lecturer of Biology

Email:  tmm15@psu.edu
Phone: 215-881-7492
Office: Woodland 230

Educational Background:
Ph.D.   Biology, The Catholic University of America, Washington, DC
B.A.     Biology and English, LaSalle University, Philadelphia, PA

Research Interests and Innovations:  My current research involves the effects of the hormone human chorionic gonadotropin on breast cancer cells.  I investigate the changes in gene expression and protein production in these cells after exposure to the hormone.  I am also beginning a new collaboration in which I will investigate the expression of stress-response genes and proteins in these cells as a result of the stress of hormone exposure.

Selected publications list:

J.C. Madara, E. Pajollari, E.P. Ingersoll, and T.M. McGuire.  2009.  Determination of gene expression changes in breast epithelial cells after exposure to human chorionic gonadotropin by RT-PCR and monoclonal antibodies.  Poster presented at the Pennsylvania Academy of Science meeting, in Camp Hill, PA and abstract published in Journal of the Pennsylvania Academy of Science 82:  157.

J.C. Madara, D.S. Oman, E.P. Ingersoll, and T.M. McGuire.  2008.  Determination of gene expression changes in breast epithelial cells after exposure to human chorionic gonadotropin by real-time PCR.  Poster presented at Pennsylvania Academy of Science Meeting, Grantville, PA and abstract published in Journal of the Pennsylvania Academy of Science 81.

J.C. Madara, D.S. Oman, E.P. Ingersoll, and T.M. McGuire.  2007.  Human chorionic gonadotropin induces depression of the proliferative activity of human breast epithelial cells in vitro.  Poster presented at Pennsylvania Academy of Science Meeting, Monroeville, PA and abstract published in Journal of the Pennsylvania Academy of Science 80:  116.

T.M. McGuire, E. Carajaval, D. Katzmann, M. Wagner, E. Balzi, S. Moye-Rowley, A. Goffeau, and J. Golin.  1995.  Analysis of second site mutations that suppress the multiple drug resistance phenotype of the yeast PDR1-7 allele.  Gene 167:  151-155.

Teaching Interests and courses taught:  I teach a variety of courses in the department, mostly in the broad areas of cell and molecular biology.  My current rotation of courses includes:
            BIOL 110 Biology: Basic Concepts and Biodiversity
            BIOL 230W Biology: Molecules and Cells
            BIOL 416 Biology of Cancer
            BIOL 422W Advanced Genetics
            BIOL 439 Practical Bioinformatics
            BIOL 460 Human Genetics
            MICRB 106 Elementary Microbiology
            MICRB 107 Elementary Microbiology Laboratory
            MICRB 201 Introductory Microbiology
            MICRB 202 Introductory Microbiology Laboratory