Ph.D.   Biochemistry, University of Missorui, Columbia MO
M.Sc   Microbiology, Seould National University, Seoul Korea
B.A.     Biology (major) and Chemistry (minor), Sogang University, Seoul Korea

My main research interests are protein structure and molecular mechanism of protein interaction and function. My past research work was mostly on protein solution structures and protein interactions. I use NMR spectroscopy supplemented with molecular and biochemical techniques. My approach is often include computational and synthetic chemistry through collaborations.

Rodriguez, J.M., Ross, N.T., Dhar, D., Lee, G., and Hamilton, A.D., Structure and Function of Benzoylurea Derived alpha-Helix Mimetics Targeting Bcl-xL/Bak. ChemMedChem. 2009, 4(4): 649-56.

Rodriguez, J.M., Nevola, L., Ross, N.T., Lee, G., and Hamilton, A.D., Synthetic Inhibitors of Extended Helix-Protein Interactions Based on a Biphenyl 4,4-Dicarboxamide Scaffold. ChemBioChem, 2009, 10(5): 829-33

Slivka, P. F., Shridhar, M., Lee, G., Sammond, D. W., Hutchinson, M. R., Martinko, A. J., Buchanan, M. M., Sholar, P. W., Kearney, J. J. Harrison, J. A., Watkins, L. R., Yin, H.
A Peptide Antagonist of the TLR4/MD2 Interaction ChemBioChem 2009, 10(4): 645-9.

Yin H., Lee, G., Hamilton, A. D. Alpha-Helix Mimetics in Drug Discovery in Post Genomic Drug (Huang, Z. W. Ed., Wiley-VCH), 2007 Chapter 11: 281-299.

Liang X., Lee G., Van Doren. S. R. Partially Unfolded Forms and Non-two-state Folding of a beta-Sandwich: FHA Domain from Arabidopsis Receptor Kinase-associated Protein
Phosphatase. 2006, J. Mol. 364(2): 225-40.

Lee, G., Ding Z., (contributed equally) Liang X, Gallazzi F, Arunima A, Van Doren SR.
PhosphoThr Peptide Binding Globally Rigidifies Much of the FHA Domain from
Arabidopsis Receptor Kinase-Associated Protein Phosphatase, Biochemistry. 2005,
44(30), 10119-10134.

Yin, H., Lee, G., Sedey, K. A., Kutzki, O., Park, H. S., Orner, B. P., Ernst, J. T., Wang, H. G., Sebti, S. M., Hamilton, A. D, ╥Terphenyl-Based Alpha-Helical Proteomimetics
as Low-Molecular-Weight Antagonists of Bcl-xL, J. Am. Chem. Soc. 2005, 127,
10191-10196.

Yin, H., Lee, G.. Park, H. S., Rodriguez, J. M., Payne, G. J., Sebti, S. M., Hamilton, A. D. Terphenyl Derivatives as Alpha-Helical Mimetics of P53, Angew. Chem. 2005, 117,
2764-2767; Angew. Chem. Int. Edit. 2005, 44, 2704-2707 (chosen as a "Hot Paper" by the editors for its importance in a rapidly evolving field of high current interest).

Yin H., Lee, G., Sedey, K. A., Rodriguez, J. M., Wang, H. M., Sebti, S. M.; Hamilton, A. D. Terephthalamide Derivatives as Mimetics of Helical Peptides: Disruption of the Bcl-
xL/Bak Interaction, J. Am. Chem. Soc. 2005, 127, 5463-5468.

Lee, G., Li, J., Walker, J. C. , Van Doreen, S., R., 1H, 13C and 15N Resonance Assignments of the Kinase interacting FHA Domains of Arabidpsis thaliana  Kinase Associated Protein
Phosphatase. J. Biomol. NMR, 2003 25(3):253-254.

Lee, G, Ding, Z., Walker, J. C. , Van Doreen, S., R., Interacting FHA Domain from the
Arabidopsis Phosphates KAPP Suggests Minimal Features Shared by FHA domains Pro.
Nat. Aca. Sci, 2003, 100(20):11261-11266.

Wu, B., Arumugam, S., Gao, G., Lee, G., Semenchenko, V., Huang, W., Brew, K., and Van Doreen, S., R., NMR Structure of Tissue Inhibitor of Metalloproteinases-1 Implicates Localized Induced Fit in Recognition of Matrix Metalloproteinases J. Mol. Biol, 2000, 295(2):257-268 .

Li, J., Lee, G., Van Doreen, S., R., Walker, J. C., Review, The FHA Domain Mediates
Phosphoprotein Interactions J. Cell Sci., 2000, 113: 4143-4149.

Nam, K., Lee, G., Trambely, J., Devine, S., and Boeke, J., D., Severe Growth Defect in a
Schizosaccharomyces Pombe Mutant Defective in Intron Lariat Degradation  Mol.  Cell
Biol., 1997, 17, 809-818.

Biochemistry
General Chemistry and Laboratory
Organic Chemistry and Laboratory

Charles W. Gehrke, Jr. Memorial Scholarship, University of Missouri-Columbia
Travel scholarship for Keystone Symposium, Frontier of Structural Biology
Travel award for International conference on magnetic resonance in biological systems
Seoul National University Scholarship for outstanding students
Sogang University Scholarship for outstanding students